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To assure proper dosage, weigh the cat prior to treatment. Select the number of whole or partial tablets needed for the cat from the following table. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Local irritation or swelling at the site of subcutaneous injections have been reported for cats. Large roundworms and hookworms pass eggs in the feces of the cat that can only be observed with the aid of a microscope. emot.info aprovel

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The dosage of Droncit Injectable solution for removal of E. multilocularis is the same as that indicated for the removal of the other tapeworm species listed on the label. Laboratory efficacy studies have demonstrated the recommended dosage is 100% efficacious for removal of this tapeworm. Watt G, Baldovino PC, Castro JT, Fernando MT, Ranoa CP "Bloody diarrhoea after praziquantel therapy. Droncit praziquantel has been tested in breeding and pregnant dogs and cats. No adverse effects were noted.

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Soulsby EJL. 1982. Helminths, Arthropods and Protozoa of Domesticated Animals. Oral exposure can cause salivation and vomiting. Treatment at the base of the head will minimize the opportunity for ingestion while grooming. In households with multiple pets, keep animals separated to prevent licking of the application site. Leblanc R, Knowles KF, Melanson D, MacLean JD, Rouleau G, Farmer JP "Neurocysticercosis: surgical and medical management with praziquantel. Swallow tablets or portions of tablets whole without chewing; take with water during meals.

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RETREATMENT: Steps should be taken to prevent parasite infections, otherwise retreatment will be necessary. Flisser A, Madrazo I, Plancarte A, Schantz P, Allan J, Craig P, Sarti E "Neurological symptoms in occult neurocysticercosis after single taeniacidal dose of praziquantel. Not intended for use in puppies less than four 4 weeks of age. Echinococcus multilocularisis a tapeworm species ordinarily considered to be found in wild canids, including foxes, coyotes and wolves. The parasite has also been identified in domestic dogs and cats and potentially is a serious public health concern by involving humans as accidental intermediate hosts.



Store at or below 77ºF 25ºC

Enrofloxacin is bactericidal and exerts its antibacterial effect by inhibiting bacterial DNA gyrase a type II topoisomerase thereby preventing DNA supercoiling and replication which leads to cell death. 1 Enrofloxacin is active against Gram-negative and Gram-positive bacteria. Drugs other than those listed here may also interact with pyrantel. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. To ensure the entire contents of the tube are administered, place the tip of the tube on the skin and squeeze the entire contents directly onto the skin. Lift tube away from the skin before releasing pressure on the tube. The daily dose has been given in 3 divided doses. Tablets may be given directly by mouth or offered in a small amount of food. Do not withhold food from the cat prior to or after treatment. Bayer, the Bayer Cross, and Drontal are registered trademarks of Bayer. An injection site study conducted in feeder calves demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue and underlying muscle. No painful responses to administration were observed. Dose Tolerance Study in Cats: Profender Topical Solution was applied topically one time to young cats at 10X the recommended label use rate. Two cats salivated. Another cat exhibited tremors and lethargy. These signs were self-limiting. Tapeworms Dipylidium caninum, Taenia taeniaeformis Hookworms Ancylostoma tubaeforme and Large Roundworms Toxocara cati in cats and kittens. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Nervous system side effects have included dizziness, drowsiness, insomnia, and headache. The inflammatory reaction produced by antigenic substances released from dying cysts frequently involved increased intracranial pressure, seizures, severe headaches, nausea, and vomiting. In areas where Taenia solium was endemic, these reactions may occur as the result of undiagnosed cysticercosis in patients being treated for other parasitic infections. The duration of the reaction differs among patients. Delayed reactions have been reported. Take each dose with a full glass of water. Plus Anthelmintic Tablets. In addition, 103 dogs and puppies were included in clinical field studies conducted in 5 veterinary clinics at different geographic locations throughout the United States to further evaluate safety and efficacy. These studies included dogs of various sizes, ages and breeds. Data from these studies demonstrated Drontal Plus Anthelmintic Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Results obtained in the laboratory and clinical studies indicate small numbers of hookworm or roundworm eggs may be passed in the feces for up to 7 days after treatment although the worms themselves were eliminated. A follow-up fecal examination should be conducted 2 to 4 weeks after treatment to determine the need for retreatment.



Bayer HealthCare LLC, used under license

Store pyrantel at room temperature away from moisture and heat. What happens if I miss a dose? Tapeworm segments are white, pinkish-white or yellow-white in color and are similar in size and shape to flattened grains of rice. The segments are most frequently observed lying on a freshly passed stool. Store at or below 77ºF 25ºC. Craig PS and McPharson CNL. 1988. Sodium Hypochlorite as an Ovicide for Echinococcus. Ann Trop Med and Parasit 822 211-213. Plus Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Plus Tablets demonstrate that each of the three active ingredients act independently without interference. The combined tablet formulation provides a wide spectrum of activity against the indicated species of intestinal helminths. Domestic dogs living in E. multilocularisendemic areas that roam freely with the opportunity to catch wild rodents are at risk of infection. Pet owners should be advised on how to minimize this risk. amiloride



KEEP OUT OF REACH OF CHILDREN

Cats become infected with large roundworms by swallowing infective eggs, particularly while grooming, or by ingestion of mice that may be infected with larval stages. Available in bottles of 50 tablets. Field study: In a controlled, double-masked field safety study, owners administered Profender Topical Solution to 606 cats. No clinical signs of toxicity or changes in clinical pathology parameters were observed. No articular cartilage lesions were observed inthe stifle joints at any dose level at 2 days and 9 days following 15 days of drug administration. Steps should be taken to prevent parasite infections otherwise retreatment will be necessary. Our Biltricide praziquantel Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Broad Spectrum Anthelmintic Tablets are indicated for removal of Tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis. For removal of Hookworms Ancylostoma caninum, Uncinaria stenocephala Ascarids Toxocara canis, Toxascaris leonina and Whipworms Trichuris vulpis in dogs. The life cycle of the parasite is based on a predator-prey relationship as depicted. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings outside of normal range at 6 days post-treatment. Do not keep tablets or portions of tablets in your mouth; the bitter taste may cause gagging or vomiting. Craig PS and McPharson CNL. 1988. Sodium Hypochlorite as an Ovicide for Echinococcus. Ann Trop Med. and Parasit. 822: 211-213. Hookworms are small whitish or reddish-brown worms less than one inch in length that live in the intestinal tract and feed on blood. Cats can become infected with hookworms by swallowing infective larvae while grooming or when larvae from the environment burrow through the skin. Cats infected with hookworms may have poor physical condition, dull haircoat, reduced body weight and diarrhea, sometimes with the presence of dark blood. Plus Anthelmintic Tablets on pregnant animals have not been determined. Dermatologic side effects have included skin rashes. You should not take this medicine if you are allergic to praziquantel, or if you have take rifampin Rifadin, Rifater, Rifamate in the last 4 weeks. General Safety Study in Kittens: Profender Topical Solution was topically applied at 0X vehicle control 1X, 3X and 5X the maximum dose to 48 healthy 8-week-old kittens every two weeks for six doses. One 5X kitten experienced salivation and tremors and another 5X kitten experienced salivation on the day of dosing. A third 5X kitten experienced tremors the day after dosing. Three cats vomited within 24 hours of dosing, one each in vehicle control, 3X and 5X groups.



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DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels 6 consecutive days with 3 times the labeled dosage rate of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities. PD Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis, Ill. Host Occurrence and Geographic Distribution of Echinococcus multilocularisin the North Central United States. J. Parasit. 566: 1141-1150. Freedom of Information Summary FOI NADA 133-953 Vercom Paste febantel and praziquantel. The time interval between individual doses should not be less than 4 hours and not more than 6 hours. Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of the product in foreign markets: application site reaction hair loss, dermatitis, pyoderma, edema, and erythema salivation, pruritus, lethargy, vomiting, diarrhea, dehydration, ataxia, loss of appetite, facial swelling, rear leg paresis, seizures, hyperesthesia, twitching, and death. kenalog purchase



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Bayer HealthCare LLC, used under license. United States. Data indicates most cats are cleared of their parasite infections within 7 days of treatment. These studies demonstrated Drontal Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Roundworms and hookworms are controlled by maintaining the cat's environment free of infective eggs and larvae. Feces and soiled litter should be removed on a daily basis to prevent build-up of eggs and larvae in the environment. Post-Approval Experience: Although not all adverse reactions are reported, based on voluntary post-approval reporting, transient ataxia has been reported following the administration of Drontal Tablets for Cats and Kittens. Broad Spectrum Chewable Anthelmintic Tablets are indicated for removal of Tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis and for removal of Hookworms Ancylostoma caninum, Uncinaria stenocephala Ascarids Toxocara canis, Toxascaris leonina and Whipworms Trichuris vulpis in dogs. Animals Using a Biological Assay. Do not take other anti-worm medicines at the same time as pyrantel unless otherwise directed by your doctor. Other drugs used to treat infections caused by worms may decrease the effectiveness of pyrantel. Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System CNS disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures. Quinolone-class drugs have been shown to produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species. See Animal Safety section for additional information. Laboratory efficacy and clinical studies conducted with Drontal Plus Anthelmintic Tablets demonstrate that each of the three active ingredients act independently without interference. The combined tablet formulation provides a wide spectrum of activity against the indicated species of intestinal helminths. Watt G, White NJ, Padre L, Ritter W, Fernando MT, Ranoa CP, Laughlin LW "Praziquantel pharmacokinetics and side effects in Schistosoma japonicum-infected patients with liver disease. Plus on pregnant animals have not been determined. Assistance in the diagnosis of E. multilocularis may be available from a state veterinary diagnostic laboratory. Domestic dogs living in E. multilocularis endemic areas that roam freely with the opportunity to catch wild rodents are at risk for infection. Pet owners should be advised on how to minimize this risk. Proper restraint of roaming dogs should be encouraged, along with regular treatment with Droncit Injectable solution, following the dosing schedule aforementioned and precautions indicated below. Not for human use. Keep out of reach of children.



Symptoms of overdosage 33

Cats maintained under conditions of constant exposure to parasite infections should have a follow-up fecal examination within 2 to 4 weeks after the first treatment. Pyrantel pamoate is active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite. The adult tapeworm is small 1-4mm and resides in the intestinal tract of the definitive host wild or domestic canids. Eggs from the adult tapeworm are shed in the feces. Rodents such as mice and voles serve as the intermediate host. Eggs ingested by rodents develop in the liver, lungs and other organs to form multilocular cysts. The life cycle is completed after a canid consumes a rodent infected with cysts. Larvae within the cyst develop into adult tapeworms in the intestinal tract of the canid. Eggs may be passed in the feces of the canid approximately 28 days later. There was no evidence of carcinogenic effect in laboratory animal models. Georgi JR and Georgi ME. 1990. Parasitology for Veterinarians. Markwalder K, Hess K, Valavanis A, Witassek F "Cerebral cysticercosis: treatment with praziquantel. Report of two cases. Gagging and vomiting have been reported due to the bitter taste of the tablets. Praziquantel may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Droncit Injectable in field trials. For dogs the majority of these were described as brief pain responses following injections to larger dogs weighing over 50 lbs. Use a dose-measuring spoon, cup, or dropper not a regular tablespoon to ensure that you measure the correct dose of medication. Ask your pharmacist where you can get a dose-measuring device if you do not have one. Tablets in a clinical field study did not exhibit any drug related side effects. A temporary loss of appetite was reported for one cat and transient loose stools were observed in a second cat. F; however such exposure should be minimized. Praziquantel should be taken with a meal. Mazzotti reaction after treatment with ivermectin, praziquantel, and albendazole for presumptive schistosomiasis and strongyloidiasis. Six days after receiving standard empiric therapy, he developed epigastric pain, vomiting, and urticaria. This progressed in 4 hours and included fever, general myalgia, and edema of the face, lower extremities, and penis accompanied by urticaria of the arms, legs, and trunk. He was diagnosed with a Mazzotti reaction and treated with methylprednisolone; symptoms subsided within 12 hours. generic to sinequan



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Do not administer to weak or debilitated animals. Do not administer this drug to breeding animals or to animals kept for breeding purposes. In a field study, Profender Topical Solution was used in cats receiving other frequently used products including: analgesics, anti-fungals, nonsteroidal anti-inflammatories, anthelmintics, antimicrobials, flea and tick products, sedatives, anesthetics, cardiac medications, anxiolytics, hormonal treatments, steroids, otic and ophthalmic preparations, and vaccines. Do not crush or chew the praziquantel tablet or portion of a tablet. Swallow the pill whole. Plus Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. Lieby PD, Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis, Ill. Host Occurrence and Geographic Distribution of Echinococcus multilocularis in the North Central United States. J. Parasit. 566: 1141-1150. Broad Spectrum Dewormer Tablets for Cats and Kittens are scored for easy breakage. Tablet dosage during safety studies showed signs of vomition and salivation without other adverse effects. Biltricide praziquantel is an anthelmintic, or anti-worm, medication used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Carribean, and parts of Asia. Biltricide is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. Tablets have 3 scores; each segment contains 150 mg of praziquantel. Bada JL, Trevino B, Cabezos J "Convulsive seizures after treatment with praziquantel. Bayer, the Bayer Cross, and Baytril are trademarks of Bayer. Ciferri F "Delayed CSF reaction to praziquantel. Since pyrantel is usually taken in one dose, you are not likely to miss a dose. What happens if I overdose? ECHINOCOCCUS MULTILOCULARIS: Echinococcus multilocularis is a tapeworm species usually found in wild canids, including foxes, coyotes and wolves. The parasite has also been identified in domestic dogs and cats and is potentially a serious public health concern because it may infect humans.



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Praziquantel may also be used for purposes not listed in this medication guide. What is the most important information I should know about praziquantel? Dogs: Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus and for the removal and control of Echinococcus multilocularis. Cats: Taenia taeniaeformis and Dipylidium caninum. Stelma FF, Talla I, Sow S, Kongs A, Niang M, Polman K, Deelder AM, Gryseels B "Efficacy and side effects of praziquantel in an epidemic focus of schistosoma mansoni. When schistosomiasis or fluke infection is associated with cerebral cysticercosis, hospitalization of the patient for the duration of therapy is recommended. It is possible that some side effects of praziquantel may not have been reported. Under condition of continual exposure to wild rodents, retreatment of the dog at 21-26 day intervals is recommended to prevent the shedding of infectious eggs. Grapefruit and grapefruit juice may interact with praziquantel and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. The tablets were offered free-choice to the dogs by their owners and over 89% of the dogs willingly consumed the tablets. Additional information on the life cycle and epidemiology of this parasite is available in veterinary parasitology texts. Certain parasites such as tapeworms and large roundworms are transmitted to the cat after they eat infected rodents. Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal. toprol



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Diagnosis of E. multilocularis in canids is difficult. The adult tapeworm produces no clinical signs of infection. Tapeworm segments proglottids are usually not observed in the feces. E. multilocularis eggs, observed using microscopic fecal examination procedures, are similar in appearance to those of common species such as Taenia pisiformis. Assistance in the diagnosis of E. multilocularismay be available from a state veterinary diagnostic laboratory. Take this medication with a full glass 8 ounces of water. Large roundworms are white or yellow-white strands 2-7 inches in length similar in size and color to smooth strings of spaghetti that may be observed in the cat's vomit or feces. Cats become infected with large roundworms by swallowing infective eggs, particularly while grooming, or by ingestion of mice that may be infected with larval stages. Data from these studies demonstrated Profender Topical Solution is safe and effective for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme adults, immature adults, and fourth stage larvae roundworm infections caused by Toxocara cati adults and fourth stage larvae and tapeworm infections caused by Dipylidium caninum adults and Taenia taeniaeformis adults. The safety and efficacy of this formulation in species other than cattle and swine have not been determined. Homeida MM, Eltom IA, Sulaiman SM, Ali HM, Bennett JL "Tolerance of two brands of praziquantel. Gastrointestinal side effects have included nausea, vomiting, diarrhea, abdominal cramps. Un-blistered whole or partial tablets should be stored in a tightly sealed container. Domestic dogs living in E. multilocularis endemic areas that roam freely with the opportunity to catch wild rodents are at risk of infection. Pet owners should be advised on how to minimize this risk. Plus Tablets, following the dosing schedule aforementioned and precautions indicated below. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Each tablet size is available in bottles of 50 puppies and small dogs, medium sized dogs or 30 large dogs. Profender Topical Solution may be irritating to skin and eyes. Reactions such as facial, tongue and hand swelling have been reported in humans in rare instances. Avoid contact with the application area while it is wet and wash hands thoroughly with soap and warm water after handling. People with known hypersensitivity to butylhydroxyanisole, emodepside or praziquantel should administer the product with caution. If the product accidentally gets into eyes, flush thoroughly with water. May be harmful if swallowed. In case of accidental ingestion or if skin or eye irritation occurs, call a poison control center or physician for treatment advice. The adult tapeworm is small 1-4mm and resides in the intestinal tract of the definitive host wild or domestic canids. Eggs from the adult tapeworm are shed in the feces. Rodents such as mice and voles serve as the intermediate host. Eggs ingested by rodents develop in the liver, lungs and other organs to form multilocular cysts. The life cycle is completed after a canid consumes a rodent infected with cysts. Larvae within the cyst develop into adult tapeworms in the intestinal tract of the canid. Tablets were conducted at 3 different veterinary clinics in the United States. Shorter D, Hale K, Elliott E "Mazzotti-like Reaction After Treatment with Praziquantel for Schistosomiasis.



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Not intended for use in kittens less than six 6 weeks of age. If reinfection with tapeworms, hookworms or large roundworms occurs, treatment with Drontal Tablets may be repeated. TABLETS DOSAGE CHARTS NOT FOR USE IN PUPPIES LESS THAN 3 WEEKS OF AGE OR DOGS WEIGHING LESS THAN 2 LBS. KEEP OUT OF REACH OF CHILDREN. Hildreth MB Johnson MD and Kazacos KR. 1991. A Zoonosis of Increasing Concern in the United States. Compendium for Cont. Ed. 135: 727-740. Always consult a healthcare professional for medical advice. Tablets may be repeated. order now zyrtec store uk



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Animals Using a Biological Assay

Anthelmintic Tablets. Dogs receiving up to 5 times the label dosage 35 mg praziquantel, 35 mg pyrantel pamoate and 179 mg febantel per kg of body weight for 3 consecutive days 3 times the label duration showed clinical signs of vomition and non-formed stools. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings outside of normal range at 6 days post-treatment. An injection site study conducted in pigs demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue. No painful responses to administration were observed. Soulsby EJL. 1982. Helminths, Arthropods and Protozoa of Domesticated Animals. 7th Edition. altace

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Other, less serious side effects may be more likely to occur. In a total of 13 controlled laboratory studies to establish effectiveness, 149 cats were treated with Profender Topical Solution. Retreatment in 2 to 6 weeks has been reported to increase cure.

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Bayer, the Bayer Cross, and Drontal are trademarks of Bayer. Broad Spectrum Anthelmintic Tablets are available in three sizes. Each size is scored for convenient oral administration. Some praziquantel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Polderman AM, Gryseels B, Gerold JL, Mpamila K, Manshande JP "Side effects of praziquantel in the treatment of Schistosoma mansoni in Maniema, Zaire. canadian ciprofloxacin prescription

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Some pyrantel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Certain parasites such as tapeworms and large roundworms are transmitted to the cat after they eat infected rodents. Controlling the predatory habits of cats from catching and eating rodents will prevent these parasite infections. Current guidelines should be consulted for additional information. Lieby PD, Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis. III. Host Occurrence and Geographic Distribution of Echinococcus multilocularis in the North Central United States. J Parasit 56 6 1141-1150.

The original geographic distribution of E. multilocularis was primarily confined to northern areas of North America. Current evidence indicates migration of the parasite well into the continental United States. Subcutaneous injection can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter. Quinolone Antimicrobial Agents, 2nded, 59 - 75, 1993.

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